Recent News

New Study Shows Promise for Repurposing Anti-Malarial Drug for Cancer Treatment

Posted: 1/10/2017

A new study by University of Kentucky Markey Cancer Center researchers shows that chloroquine – a drug currently used to treat malaria – may be useful in treating patients with metastatic cancers.

Published in Cell Reports, the study showed that chloroquine induced the secretion of the tumor suppressor protein Par-4 in both mouse models and in cancer patients in a clinical trial. Secreted Par-4 is essential for tumor cell death and the inhibition of tumor metastasis.

Chloroquine induces Par-4 secretion via the classical secretory pathway that requires activation of p53 (a mutation of the p53 protein, or disturbances in the pathways that signal to p53, is common in many cancers). Mechanistically, p53 directly induces Rab8b, a GTPase essential for vesicle transport of Par-4 to the plasma membrane prior to secretion. The study’s findings indicate that chloroquine induces p53- and Rab8b-dependent Par-4 secretion from normal cells for Par-4-dependent inhibition of metastatic tumor growth.

The study was led by the lab of Vivek M. Rangnekar, the Alfred Cohen endowed chair in oncology research at the UK Markey Cancer Center and a professor in the UK Department of Radiation Medicine. UK Researchers Ravshan Burikhanov and Nikhil Hebbar in Rangnekar’s group were co-... FULL STORY

Tags: Markey Cancer Center, Research
 

Resident Research Activities

Posted: 11/10/2015
Our medical residents have had several presentations and publications in national meetings. Some of these include: ASTRO 2015 Approximately 11,000 radiation oncologists, medical physicists and related experts met in San Antonio, Texas from October 18-21 to explore the theme “Technology Meets Patient Care” at the 57th Annual ASTRO meeting. Advances... FULL STORY
 

UK HealthCare Physicians Named to 2015-16 Best Doctors List

Posted: 10/7/2015
by Kristi Lopez LEXINGTON, Ky. (Oct. 7, 2015) – UK HealthCare has more than 125 physicians practicing medicine with UK Albert B. Chandler Hospital, Kentucky Children's Hospital, UK Good Samaritan Hospital and Shriner's Hospitals for Children who appear on the Best Doctors in America list for 2015-16 – more than any other hospital in Kentucky. Only... FULL STORY
 

Vivek Rangnekar's Research Laboratory

Posted: 12/5/2014
Left to Right: Nikhil Hebbar, James Sledziona, Ping Du, Ablesh Gautam, Tripti Shrestha-Bhattarai, Hannah Latta, Vivek Rangnekar, Nathalia Vitori Araujo, Sunil Nooti, Ravshan Burikhanov.   Dr. Vivek Rangnekar's Laboratory identified a novel tumor suppressor that they named Par-4 (prostate apoptosis response-4, later also called PAWR). Par-4 protein is secreted by normal cells and it selectively induces apoptotic death of primary and metastatic cancer cells. Researchers in the Rangnekar Laboratory are using novel molecular and chemical biology approaches to induce robust secretion of Par-4 from normal cells for inhibition of a broad range of tumors. Par-4... FULL STORY

UK Study Identifies Molecule That Induces Cancer-killing Protein

Posted: 9/15/2014 - Tags: Radiation Medicine
A new study by University of Kentucky researchers has identified a novel molecule named Arylquin 1 as a potent inducer of Par-4 secretion from normal cells. Par-4 is a protein that acts as a tumor suppressor, killing cancer cells while leaving normal cells unharmed. Normal cells secrete small amounts of Par-4 on their own, but this amount is not enough to kill cancer cells. Notably, if Par-4 secretion is suppressed, this leads to tumor growth. Published in "Nature Chemical Biology," the UK study utilized lab cultures and animal models to show that low levels of Arylquin 1 induced Par-4 secretion without causing harm to the producer cells. Additionally,... FULL STORY

Ironcology

Posted: 9/3/2014
 Dr. Jonathan Feddock, in addition to being a member of our faculty, performs regularly in Ironman distance triathlons.  In 2014, he created a fundraiser titled Ironcology, as a means of combining his talents as an Ironman triathlete with improving cancer care, or Oncology, at our cancer center.  Specifically, in 2014 he was trying to raise funds for a new brachytherapy suite.  He competed in the 2014 Ironman Louisville and started the race as the final athlete.  He collected donations and pledges based on how many people he could pass throughout the day.  It turned out to be a very successful day, as he caught nearly 2000 people which... FULL STORY

Silent Auction Benefits Shoulder to Shoulder Clinic in Ecuador

Posted: 4/2/2014 - Tags: Medical Education, Auction
The University of Kentucky Chapter of the International Federation of Medical Student Associations (IFMSA) will host the 10th annual Art of Healing silent auction on Wednesday, April 2. The auction will be held in Biological and Biomedical Sciences Research Building (BBSRB) atrium from noon to 5 p.m. Winning bidders may pick up their art from 5 p.m. to 6 p.m. The auction items feature the handiwork of local and international artists and current students, including pottery, paintings, wood carvings, and accessories. Proceeds from the art auction benefit the Shoulder to Shoulder clinic in Ecuador. Shoulder to Shoulder, an initiative supported by many of the... FULL STORY

Bastos-Carvalho Receives Bayer Grant

Posted: 1/13/2014 - Tags: Ophthalmology and Visual Sciences, 490
Ana Bastos-Carvalho, a visiting scholar in the Ambati research group in the Department of Ophthalmology and Visual Sciences at the University of Kentucky College of Medicine, received the Global Ophthalmology Research Award from Bayer HealthCare for her research, "Mechanisms of geographic atrophy expansion in age-related macular degeneration." http://www.bayer-ophthalmology-awards.com/html/b-about-c.html “We are studying age-related macular degeneration (AMD), the disease responsible for most cases of legal blindness in the American elderly population”, Bastos-Carvalho said. “The project awarded by Bayer focuses on unraveling how AMD progresses, which will hopefully... FULL STORY

Creating a Culture of Collaboration for Research at UK and Beyond

Posted: 1/10/2014 - Tags: CCTS, 490, Center for Clinical and Translational Science
There's a proverb in the business world that says, "If you don’t know, hire someone who does." In the world of translational research, the saying might go like something this: "If you don't have the expertise or resources, collaborate with someone who does." The nature of translational science -- the process of turning a basic science discovery into applications for human patients -- is inherently multidimensional. Moving from the "bench to bedside" is a process that runs the gamut of biomedical research, incorporating laboratory and animal studies, clinical trials, drug and device development, regulatory issues, grant writing and more. Each step requires... FULL STORY

UK's Arts In Healthcare Program Announces Holiday Programming

Posted: 12/2/2013 - Tags: Arts in Healthcare
Everyone wants to be home for the holidays. Unfortunately, hospital patients don't have that luxury. For those who are unable to enjoy the comforts of a holiday at home, the UK Arts in Healthcare program has scheduled a series of events to help bring the holidays to the hospital. Carolers, pianists, harpists and more will bring holiday cheer to patients, visitors and staff in December. Of particular note: UK HealthCare's own Dr. Jay Zwischenberger will be performing at 1 p.m., Dec. 12, in the Pavilion A of UK Chandler Hospital. Carolers from Deep Springs Elementary School will be performing at noon, Dec.13, Pavilion A of UK Chandler Hospital. Carolers from the... FULL STORY

Alzheimer’s Disease Trial at UK is First of its Kind Worldwide

Posted: 12/2/2013 - Tags: UK Sanders-Brown Center on Aging, Alzheimer's research
A new clinical trial being conducted at the University of Kentucky Sanders-Brown Center on Aging (SBCoA) and the UK Alzheimer’s Disease Center (ADC) may signal new hope in the future for those who might be afflicted with the devastating disease. Taking laboratory research pioneered at SBCoA and the associated UK ADC into human trials, the federally-funded research project will examine the therapeutic potential of microRNAs to delay or prevent Alzheimer’s disease.Led by physician-scientist Dr. Gregory Jicha, and building off of the work of fellow SBCoA physician-scientist Dr. Peter Nelson, the project, formally titled “Modulation of micro-RNA pathways by... FULL STORY

Dr. Ronan Tynan to Speak, Perform at Sanders-Brown Dinner Nov. 11

Posted: 11/5/2013 - Tags: UK Sanders-Brown Center on Aging, 490, Invited Speaker Seminar
Singer, physician, athlete and inspirational speaker Dr. Ronan Tynan is no stranger to adversity. When Tynan was 20, his legs had to be amputated below the knee after an auto accident caused serious complications. Just weeks after the operation, he was climbing up the steps of his college dorm, and within a year, he was winning gold medals in the Paralympics as a multitalented athlete. Between 1981 and 1984, Tynan amassed 18 gold medals and 14 world records, of which he still holds nine. Trained as a physician, Tynan began his remarkable singing career through formal music study at the age of 33, achieving great success as a member of the famed Irish Tenors prior to... FULL STORY

Ambati Receives Junius-Kuhnt Award

Posted: 11/1/2013 - Tags: Ophthalmology and Visual Sciences
Dr. Jayakrishna Ambati, professor and vice chair of the Department of Ophthalmology and Visual Sciences at the University of Kentucky College of Medicine, received the Junius-Kuhnt Award from the University of Bonn in Hamburg, Germany, for his group's outstanding work and commitment to age-related macular degeneration (AMD) research. The Junius-Kuhnt Award honors physicians and scientists who have made outstanding contributions to the study and treatment of AMD, and has been awarded annually since 2007 at “Makula Update,” an annual congress of German retina specialists. This award is named after the German ophthalmologists Paul Junius and Kuhnt Hermann who, at... FULL STORY

UK HealthCare Named ‘Rising Star’ Hospital by University HealthSystem

Posted: 10/18/2013 - Tags: UK HealthCare, Clinical
University HealthSystem Consortium (UHC), an alliance of the nation’s leading nonprofit academic medical centers, has named UK HealthCare among the 2013 recipients of the Rising Star Award during the UHC Annual Conference 2013 in Atlanta. The award recognizes significant improvements in ranking in UHC’s annual Quality and Accountability Study, which identifies exemplary performance in patient safety, mortality, clinical effectiveness, and equity of care. UK HealthCare has not only shown improvement from previous years, it has the highest jump in rankings in UHC’s history with a Quality and Accountability Ranking of 12th among the nation's 118 academic medical... FULL STORY

Clinical Education Research Day Highlights Research Activities,

Posted: 10/16/2013 - Tags: Center for Clinical and Translational Science, Clinical
The University of Kentucky Center for Clinical and Translational Science will host the 2nd Annual UK Clinical Research Education Day on Friday, Oct. 25, from 9 a.m. to 3 p.m. in the UK Chandler Hospital, Pavilion H North Lobby (outside of the administration offices). The free, public event will feature a variety of informational tables for patients, students, faculty, staff and visitors to learn about clinical research activities and opportunities at UK. Several departments and centers will showcase their clinical research activities, including the Center for Clinical and Translational Science (CCTS); the departments of psychology, behavioral science, pediatrics, and... FULL STORY