Recent News

New Study Shows Promise for Repurposing Anti-Malarial Drug for Cancer Treatment

Posted: 1/10/2017

A new study by University of Kentucky Markey Cancer Center researchers shows that chloroquine – a drug currently used to treat malaria – may be useful in treating patients with metastatic cancers.

Published in Cell Reports, the study showed that chloroquine induced the secretion of the tumor suppressor protein Par-4 in both mouse models and in cancer patients in a clinical trial. Secreted Par-4 is essential for tumor cell death and the inhibition of tumor metastasis.

Chloroquine induces Par-4 secretion via the classical secretory pathway that requires activation of p53 (a mutation of the p53 protein, or disturbances in the pathways that signal to p53, is common in many cancers). Mechanistically, p53 directly induces Rab8b, a GTPase essential for vesicle transport of Par-4 to the plasma membrane prior to secretion. The study’s findings indicate that chloroquine induces p53- and Rab8b-dependent Par-4 secretion from normal cells for Par-4-dependent inhibition of metastatic tumor growth.

The study was led by the lab of Vivek M. Rangnekar, the Alfred Cohen endowed chair in oncology research at the UK Markey Cancer Center and a professor in the UK Department of Radiation Medicine. UK Researchers Ravshan Burikhanov and Nikhil Hebbar in Rangnekar’s group were co-... FULL STORY

Tags: Markey Cancer Center, Research
 

Resident Research Activities

Posted: 11/10/2015
Our medical residents have had several presentations and publications in national meetings. Some of these include: ASTRO 2015 Approximately 11,000 radiation oncologists, medical physicists and related experts met in San Antonio, Texas from October 18-21 to explore the theme “Technology Meets Patient Care” at the 57th Annual ASTRO meeting. Advances... FULL STORY
 

UK HealthCare Physicians Named to 2015-16 Best Doctors List

Posted: 10/7/2015
by Kristi Lopez LEXINGTON, Ky. (Oct. 7, 2015) – UK HealthCare has more than 125 physicians practicing medicine with UK Albert B. Chandler Hospital, Kentucky Children's Hospital, UK Good Samaritan Hospital and Shriner's Hospitals for Children who appear on the Best Doctors in America list for 2015-16 – more than any other hospital in Kentucky. Only... FULL STORY
 

Center for Clinical and Translational Science Announces Pilot Funding

Posted: 10/2/2013 - Tags: Center for Clinical and Translational Science, Markey Cancer Center
The University of Kentucky Center for Clinical and Translational Science (CCTS) Pilot Funding Program announces recipients of its most recent round of pilot funding in the Collaborative Category. The mission of the Pilot Funding Program is to offer opportunities and resources necessary to support innovative intervention and early stage and collaborative research approaches in clinical and translational studies, and to promote the development of new methodologies and tools relevant to the health challenges and disparities faced by the citizens of Kentucky, Appalachia, and other rural populations. Since its inception in 2007, the CCTS Pilot Funding Program has provided... FULL STORY

16th Annual Gill Heart Institute Cardiovascular Research Day Scheduled for

Posted: 9/10/2013 - Tags: Saha Cardiovascular Research Center
The University of Kentucky Gill Heart Institute and the UK Saha Cardiovascular Research Center will host the 16th Annual Gill Heart Cardiovascular Research Day, Oct. 11, at the Lexington Convention Center. Gill Heart Insitute Cardiovascular Research Day annually attracts preeminent speakers in the field of cardiology and cardiovascular research. It also features a symposium for trainee researchers, a scientific poster session, and the presentation of the annual Saha Awards for medical and nursing education. This year, speakers include Dr. Peter Libby, Mallinckrodt Professor of Mmedicine and Cchief of Cardiovascular Medicine at Harvard Medical School and Brigham and Women... FULL STORY

College of Medicine Hosts Free Community Health Fair on Sept. 8

Posted: 9/3/2013 - Tags: Community Health Fair, Students, Undergraduate Medical Education
The University of Kentucky College of Medicine, in collaboration with the colleges of pharmacy, dentistry, nursing and public health, will host the annual free Community Health Fair from 1 to 6 p.m., Sunday, Sept. 8, at the BioPharm Building (College of Pharmacy), located at 789 South Limestone St. on UK's campus. The annual event, organized by UK College of Medicine students, targets all underrepresented, uninsured, low-income and no-income persons interested in access to free health care. Among its many services, the health fair will offer blood pressure checks, women’s health care, nutritional assessments, hearing and vision screenings, blood glucose and HbA1c... FULL STORY

Town Hall to Address Alzheimer's Information

Posted: 8/16/2013 - Tags: Alzheimer's disease
Members of the public interested in participating in research related to aging and Alzheimer's disease are invited to a town hall-style meeting to be held on Monday, Aug. 19, in Lexington. The meeting, sponsored by the University of Kentucky Sanders-Brown Center on Aging, will take place from 2 to 4 p.m. at the Fayette County Extension Office, 1140 Red Mile Place. During the town hall, participants will have the chance to hear from physicians and scientists currently engaged in research to find a cure or preventive measures for Alzheimer's disease. The researchers will describe their programs, as well as opportunities for the general public to become involved through... FULL STORY

Senior Associate Dean for Medical Education

Posted: 7/23/2013 - Tags: Undergraduate Medical Education
Effective August 1, 2013, Dr. Darrell Jennings will step down from his role as Senior Associate Dean for Medical Education to focus primarily on his role as chair in the Department of Pathology and Laboratory Medicine including the department’s acquisition of the Medical Directorship of the State Public Health Reference Lab in Frankfort. This change concludes the transition which began in August of 2012 when Dr. Jennings assumed the position of departmental chair. Dr. Jennings led the Office of Medical Education for 10 years with a focus on educational quality management and accountability, stressing a balanced approach of strategic and operational oversight.... FULL STORY

Ambati to Receive Mark Brothers Award

Posted: 7/22/2013 - Tags: Ophthalmology and Visual Sciences, Faculty
Dr. Jayakrishna Ambati, professor and vice chair in the Department of Ophthalmology and Visual Sciences and professor of physiology at the University of Kentucky College of Medicine, will receive the 2013 Mark Brothers Award from the Indiana University School of Medicine. Dr. and Mrs. Guey C. Mark created the endowed Mark Brothers Lectureship to recognize nationally and internationally renowned medical scientists of Asian descent. The Mark Brothers Lectureship was established in 1997 in honor of Dr. Mark’s brothers, who immigrated from Canton and settled in South Bend, Ind., where they built a successful restaurant business. The brothers, because of their... FULL STORY

Telehealth Expands Patient Access To Care

Posted: 7/16/2013 - Tags: Kentucky TeleCare
The following column appeared in the Lexington Herald-Leader on Sunday, July 14. By Rob Sprang Imagine that during your last visit to your mother’s home in Eastern Kentucky, you noticed that she was having memory problems. The closest memory disorder specialist is in Lexington and Mom has made it clear that she feels fine and is not going all the way to Lexington just to see the doctor. So, if you can’t bring Mom to the doctor, can you bring the doctor to Mom? In Kentucky, the answer is yes. Kentucky is a recognized national leader in the use of telehealth or interactive video conference technology used to connect patients and providers who are many miles... FULL STORY

Announcement Regarding UK's Markey Cancer Center Set for 10 a.m.

Posted: 7/12/2013 - Tags: Markey Cancer Center
University of Kentucky President Dr. Eli Capilouto will join Gov. Steve Beshear, U.S. Rep. Hal Rogers, Kentucky House Speaker Greg Stumbo, UK Vice President for Health Affairs Dr. Michael Karpf and UK Markey Cancer Center Director Dr. Mark Evers for an important announcement at 10 a.m. in the UK Chandler Hospital Pavilion A atrium. All faculty, staff, students and the public are invited to attend the announcement and may also watch the news conference via live stream at http://uknow.uky.edu.

Research Will Look for Possible Links Between AMD, Atherosclerosis

Posted: 7/11/2013 - Tags: Ophthalmology and Visual Sciences
Bradley Gelfand, assistant professor in the Department of Ophthalmology and Visual Sciences at the University of Kentucky College of Medicine, has been awarded a research grant from the American Heart Association to study atherosclerosis. The grant will be used to determine whether the same novel findings previously discovered in human age-related macular degeneration also apply to human atherosclerosis. In particular, which levels and activity of the enzyme Dicer are altered in the vessel wall during atherosclerotic lesion formation. One consequence of Dicer reduction could be the build-up of unwanted, toxic RNA's that are normally eliminated by Dicer activity. The... FULL STORY

Kleinman Receives American Federation for Aging Research Grant

Posted: 7/11/2013 - Tags: Ophthalmology and Visual Sciences, Faculty
Dr. Mark E. Kleinman, assistant professor in the Department of Ophthalmology and Visual Sciences at the University of Kentucky College of Medicine, and principal investigator in the laboratory of ocular biology and imaging, has been awarded a research grant from the American Federation for Aging Research (AFAR) to pursue his research on age-related macular degeneration. Age-related macular degeneration (AMD) is an epidemic in the developed world and the leading cause of irreversible vision loss in people over 55 years old. The hallmark of the disease is the formation of subretinal deposits called drusen that induce inflammation, spur leaky choroidal vascular in-... FULL STORY

Growth through Investment: CCTS Funding Transforms Careers, Research

Posted: 7/9/2013 - Tags: CCTS
Through early support of promising investigators in fields ranging from lung cancer to Alzheimer's disease to pediatric heart disease, the University of Kentucky Center for Clinical and Translational Science (CCTS) has seen great return on their investment in recent years in the area of biomedical imaging at UK. The growth through investment ratio in this area has been great, with the return in federally-funded grants greatly multiplying the initial investment by the CCTS in the investigators' work.  In its first three years of funding by a federal Clinical and Translational Science Award (CTSA), the CCTS has invested $652,999 in support for young... FULL STORY

Researchers Investigate Mechanism of Alzheimer's Therapy

Posted: 7/8/2013 - Tags: Alzheimer's research
Researchers at the University of Kentucky Sanders-Brown Center on Aging, led by faculty member Donna Wilcock, have recently published a new paper in the Journal of Neuroscience detailing an advance in treatment of Alzheimer's disease. Gammagard™ IVIg is a therapy that has been investigated for treatment of Alzheimer's. Despite small clinical studies that have reported efficacy of the approach, the mechanism of action is poorly understood. The UK researchers set out to investigate the mechanism by which the treatment may act in the brain to lower amyloid deposition (amyloid deposits being a key pathology in Alzheimer's). To conduct their investigation,... FULL STORY