The Department of radiation Medicine is involved in an array of research projects broadly divided between clinical and pre-clinical investigations. The principle goals of the research activities is to advance patient treatment both in terms of increasing cure rates and to minimize treatment related side-effects and improve quality of life. Faculty in Radiation Medicine collaborates with other oncologic specialist through the Markey Cancer Center.

The Department of Radiation Medicine participates in cooperative clinical trials sponsored by the national Cancer Institute (NIH) including:

A) NRG oncology (NSABP, RTOG, GOG)
C) Pediatric Oncology Group (POG)
D) Eastern Cooperative Oncology Group (ECOG)
E) Southwest Oncology Group (SWOG)
F) National Clinical Trials Networks (NCTN)

In addition to participation in cooperative trials the faculty of radiation medicine have several investigator initiated trials open; these include a) Stereotactic Body Radiation Therapy (SBRT) to treat non-painful spine metastasis, b) SBRT for early lung cancer, c) Evaluation of a new tumor marker for prostate cancer, d) Evaluation of electron beam therapy to control sialorrhea in ALS patients, e) Use of image guidance to treat chest wall reoccurrence in breast cancer patients, f) Measure blood flow in head and neck cancer patient undergoing radiation treatments and g) Evaluation of Cs-131 interstitial brachytherapy for treatment of gynecologic malignancies.

The faculties of Radiation Medicine are involved in a wide range of pre-clinical investigations.
These studies range from evaluation of new tumor markers to advanced radiation delivery methods. Collaborative projects involving faculty and staff from the Department of Pharmaceutical sciences, Division of Medical Oncology, Neurology, Graduate center for Toxicology and the Department of Biomedical Engineering. In addition to biological based research physics research is also as it applies to the delivery of therapeutic radiation therapy is of interest. Active physics projects include evaluation of Monte Carlo algorithms to optimize radiation delivery from external beam radiation and brachytherapy. Collaboration exists with Varian Medical Systems for the development of an institutional consistency metric for prevention of errors in Radiation Oncology.